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The Hoodia Gordonii plant has been used by the San Bushmen of the Kalahari desert long before Europeans came into contact with it.
It was invaluable to them to ward off hunger during their lengthy nomadic trips through the desert.
They also used it medically for a number of other issues such as abdominal cramps, indigestion, hemorrhoids and tuberculosis.
The plant is a succulent that grows in the high deserts of the Kalahari Desert region of South Africa. It has appeared on the weight management scene only recently (since early 2004) in the west, but has been used for millennia by the San people of the Kalahari a tribe of hunter-gatherers to help ward off pain, hunger and thirst when the Bushmen made long trips in the desert
The plant has an appetite-suppressing component P57, which pharmaceutical companies are trying to synthesise so that they can patent it, but, until that happens, this plant is the only source
Hoodia gordonii is not a stimulant, and has no known side effects
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(refer also to statements below)
There are no negative side effects reported for the use of this herb
A major claim made for Hoodia is that it does not produce the same unpleasant side effects as other appetite suppressants.
Recent News Comment....
Sustainable hoodia to secure supply, lower prices
FoodNavigator.com, France - Feb 21, 2007
Research into its appetite suppressing properties and the isolation of the active ingredient P57......
Weight-loss industry's latest hope
Baltimore Sun, MD - Feb 16, 2007
... project being carried out by Namibia's National Botanical Research Institute, which is part of a working group helping indigenous people farm hoodia . ...

There is limited research published so far about Hoodia.
Research carried out at Brown University in Rhode Island recently suggests that the steroidal glycosides in hoodia affects nerve cells in the hypothalamus that monitor blood glucose.
It appears that the effect of this is that the brain thinks that the body has sufficient blood sugar and doesn't need to eat more and shuts down the hunger mechanism.
The first human clinical trial was reputedly conducted by Phytopharm in which a group of morbidly obese men and women was placed in a place as close to prison as it gets. All they could do was read, watch television -- and eat. Half the group were given Hoodia and half were given a placebo. At the end of 15 days, the group on Hoodia had reduced their food intake by 1000 calories a day( compared with the average daily diet of around 2200 calories)
More recently, in two double-blind studies lean and obese laboratory rats were given Hoodia which brought about major weight loss in the obese rats and moderate appetite suppression and weight loss in the lean rats. Hoodia also induced a modest drop in the rats' blood sugar levels, and no adverse side effects were reported.
News Comment on Hoodia Gordonii
Health Solutions, the company that brought award winning ...
PR-Inside.com (Pressemitteilung), Austria - 28 Feb 2008
2008-02-28 20:17:27 - Taken orally in tablet form, hoodia suppresses appetite, providing easy and stress free dieting and calorie reduction for almost ...
Hoodia weight management on schedule for 2009
FoodNavigator.com, France - Feb 2008
The firm set out in 2005 on a five-stage development programme to research products using the active extract of hoodia gordonii . ...
Three presidents open ‘international gate‘
The Herald Eastern Cape, South Africa Oct 2007
The opening of Mata-Mata will also facilitate the development of the hoodia industry, he said. An indigenous plant traditionally used as an appetite ...
Hoodia For Appetite Suppression And Weight Loss
Best Syndication, CA - Nov 2006
Hoodia is one of the substances that I just keep hearing about over and over so I wanted to do some research and pass it on. Hoodia ...
'Diet plant' under threat
Independent Online, South Africa - Nov 2006
Hoodia is a southern African plant used by the San for thousands of years as an appetite suppressant and thirst quencher. It is ...
Millennium Health Supplements: All Hoodia is not alike
NPIcenter (press release), Canada - Nov 2006
Respected BBC Journalist Tom Mangold, in conjunction with Millennium Health Supplements (the largest exporter of South African Hoodia Gordonii in the world ...
Weight Loss Effects of Hoodia Leads to Wide Public Interest
PR Web (press release), WA - Apr 2006
... Hoodia Gordonii and has been used for centuries by the San Bushmen of South Africa as a way of controlling hunger and thirst during hunting expeditions in the ...