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Traditional Uses
Some anti-inflammatory and pain-relieving effects associated with sarsaparilla made it useful in early medicine for treating arthritis and related conditions.
Current uses
Sarsaparilla has been used as an oral remedy for skin conditions such as psoriasis. by eliminating or reducing the amounts of endotoxins left over from bacterial activity.
Orally, sarsaparilla also has weak diuretic and laxative effects and has been used to relieve mild constipation. It may also promote sweating, which may help to reduce fever. It also acts as a mild expectorant – a substance that may loosen bronchial mucus and promote coughing..

Precautions and side effects (refer also to statements below)
There are no consistently reported side effects.
Research
Very little research is documented on the medicinal properties of sarsaparilla.
In a recent study, the inflammation of artificially induced arthritis was blocked in a significant number of laboratory animals that were given oral sarsaparilla.